Recent advances in the field of agent/multiagent systems brings us closer to agents acting in real world domains, which can be uncertain and many times adversarial. Security, commonly defined as the ability to deal with intentional threats from other agents is a major challenge for agents or agent-teams deployed in these adversarial domains. Such adversarial scenarios arise in a wide variety of situations that are becoming increasingly important such as agents patrolling to provide perimeter security around critical infrastructure or performing routine security checks. These domains have the following characteristics: (a) The agent or agent-team needs to commit to a security policy while the adversaries may observe and exploit the policy committed to. (b) The agent/agent-team potentially faces different types of adversaries and has varying information available about the adversaries (thus limiting the agents’ ability to model its adversaries). To address security in such domains, I developed two types of algorithms. First, when the agent has no model of its adversaries, my key idea is to randomize agent’s policies to minimize the information gained by adversaries. To that end, I developed algorithms for policy randomization for both the Markov Decision Processes (MDPs) and the Decentralized-Partially Observable MDPs (Dec POMDPs). Since arbitrary randomization can violate quality constraints (for example, the resource usage should be below a certain threshold or key areas must be patrolled with a certain frequency), my algorithms guarantee quality constraints on the randomized policies generated. For efficiency, I provide a novel linear program for randomized policy generation in MDPs, and then build on this program for a heuristic solution for Dec-POMDPs. Second, when the agent has partial model of the adversaries, I model the security domain as a Bayesian Stackelberg game where the agent’s model of the adversary includes a probability distribution over possible adversary types. While the optimal policy selection for a Bayesian Stackelberg game is known to be NP-hard, my solution approach based on an efficient Mixed Integer Linear Program (MILP) provides significant speedups over existing approaches while obtaining the optimal solution. The resulting policy randomizes the agent’s possible strategies, while taking into account the probability distribution over adversary types. Finally, I provide experimental results for all my algorithms, illustrating the new techniques developed have enabled us to find optimal secure policies efficiently for an increasingly important class of security domains.